Toward Multitasking Pharmacological COX-Targeting Agents: Non-Steroidal Anti-Inflammatory Prodrugs with Antiproliferative Effects

Toward Multitasking Pharmacological COX-Targeting Agents: Non-Steroidal Anti-Inflammatory Prodrugs with Antiproliferative Effects

The antitumor activity of certain anti-inflammatory drugs is often attributed to an indirect effect based on the inhibition of COX enzymes. In the case of anti-inflammatory prodrugs, this property could be attributed to the parent molecules with mechanism other than COX inhibition, particularly thro...

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Bibliographic Details
Main Authors: Fedora Grande, Francesca Giordano, Maria Antonietta Occhiuzzi, Carmine Rocca, Giuseppina Ioele, Michele De Luca, Gaetano Ragno, Maria Luisa Panno, Bruno Rizzuti, Antonio Garofalo
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
COX-1
COX-2
nabumetone
molecular docking
anti-enzymatic assays
cell toxicity
Online Access:https://www.mdpi.com/1420-3049/26/13/3940

Internet

https://www.mdpi.com/1420-3049/26/13/3940

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