Celastrol-Induced Suppression of the MiR-21/ERK Signalling Pathway Attenuates Cardiac Fibrosis and Dysfunction

Celastrol-Induced Suppression of the MiR-21/ERK Signalling Pathway Attenuates Cardiac Fibrosis and Dysfunction

Backgroud: Myocardial fibrosis results in myocardial remodelling and dysfunction. Celastrol, a traditional oriental medicine, has been suggested to have cardioprotective effects. However, its underlying mechanism is unknown. This study investigated the ability of celastrol to prevent cardiac fibrosi...

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Bibliographic Details
Main Authors: Mian Cheng, Gang Wu, Yue Song, Lin Wang, Ling Tu, Lizhi Zhang, Cuntai Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Micro RNA-21
Celastrol
ERK
Myocardial fibrosis
Online Access:http://www.karger.com/Article/FullText/445554

Internet

http://www.karger.com/Article/FullText/445554

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