A FFAR1 full agonist restores islet function in models of impaired glucose-stimulated insulin secretion and diabetic non-human primates

A FFAR1 full agonist restores islet function in models of impaired glucose-stimulated insulin secretion and diabetic non-human primates

The free fatty acid receptor 1 (FFAR1/GPR40) mediates fatty acid-induced insulin secretion from pancreatic β-cells. At least 3 distinct binding sites exist on the FFAR1 receptor and numerous synthetic ligands have been investigated for their anti-diabetic actions. Fasiglifam, binds to site-1 and sti...

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Bibliographic Details
Main Authors: Brian Rady, Jianying Liu, Hui Huang, Ivona Bakaj, Jenson Qi, S. P. Lee, Tonya Martin, Lisa Norquay, Mark Player, Alessandro Pocai
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Endocrinology
Subjects:
Diabetes
human islet
insulin
glucagon
GLP-1
non-human primate
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1061688/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.1061688/full

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