Novel Nitrogen-Based Chalcone Analogs Provoke Substantial Apoptosis in HER2-Positive Human Breast Cancer Cells via JNK and ERK1/ERK2 Signaling Pathways

Novel Nitrogen-Based Chalcone Analogs Provoke Substantial Apoptosis in HER2-Positive Human Breast Cancer Cells via JNK and ERK1/ERK2 Signaling Pathways

Natural chalcones possess antitumor properties and play a role as inducers of apoptosis, antioxidants and cytotoxic compounds. We recently reported that novel nitrogen chalcone-based compounds, which were generated in our lab, have specific effects on triple-negative breast cancer cells. However, th...

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Bibliographic Details
Main Authors: Balsam Rizeq, Ishita Gupta, Hadeel Kheraldine, Dana Elkhalifa, Halema F. Al-Farsi, Ala-Eddin Al Moustafa, Ashraf Khalil
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
chalcones
HER2-positive
breast cancer
chemoprevention
apoptosis
Online Access:https://www.mdpi.com/1422-0067/22/17/9621

Internet

https://www.mdpi.com/1422-0067/22/17/9621

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