NMDA Receptor-Mediated Signaling Pathways Enhance Radiation Resistance, Survival and Migration in Glioblastoma Cells—A Potential Target for Adjuvant Radiotherapy

NMDA Receptor-Mediated Signaling Pathways Enhance Radiation Resistance, Survival and Migration in Glioblastoma Cells—A Potential Target for Adjuvant Radiotherapy

Glioblastoma is one of the most aggressive malignant brain tumors, with a survival time less than 15 months and characterized by a high radioresistance and the property of infiltrating the brain. Recent data indicate that the malignancy of glioblastomas depends on glutamatergic signaling via ionotro...

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Bibliographic Details
Main Authors: Adriana Müller-Längle, Henrik Lutz, Stephanie Hehlgans, Franz Rödel, Kerstin Rau, Bodo Laube
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
ionotropic glutamate receptors
DNA repair
CREB inhibitor
NMDAR subunit GluN2B
radiotherapy
LN229
U-87MG
memantine
ifenprodil
sulfasalazine
Online Access:https://www.mdpi.com/2072-6694/11/4/503

Internet

https://www.mdpi.com/2072-6694/11/4/503

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