Whole blood transcriptomics reveals the enrichment of neutrophil activation pathways during erythema nodosum leprosum reaction

Whole blood transcriptomics reveals the enrichment of neutrophil activation pathways during erythema nodosum leprosum reaction

IntroductionPatients with the multibacillary form of leprosy can develop reactional episodes of acute inflammation, known as erythema nodosum leprosum (ENL), which are characterized by the appearance of painful cutaneous nodules and systemic symptoms. Neutrophils have been recognized to play a role...

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Main Authors: Thabatta Leal Silveira Andrezo Rosa, Thyago Leal-Calvo, Isabella Forasteiro Tavares, Mayara Abud Mendes, André Alves Dias, Meire Hellen dos Santos Piauy, Marcella Feitosa da Silva Barboza, Marylee Kapuscinski, Fabrício da Mota Ramalho Costa, Maria Angela M. Marques, Andrea de Faria F. Belone, Anna Maria Sales, Mariana de Andrea Hacker, Marcia de Berredo Pinho Moreira, John T. Belisle, Milton Ozório Moraes, Maria Cristina Vidal Pessolani, Veronica Schmitz
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
leprosy
erythema nodosum leprosum
neutrophils
blood transcriptomics
RNAseq
thalidomide
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1366125/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1366125/full

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