Sodium Fluoride Arrests Renal G2/M Phase Cell-Cycle Progression by Activating ATM-Chk2-P53/Cdc25C Signaling Pathway in Mice

Sodium Fluoride Arrests Renal G2/M Phase Cell-Cycle Progression by Activating ATM-Chk2-P53/Cdc25C Signaling Pathway in Mice

Background/Aims: Excessive fluoride intake can induce cytotoxicity, DNA damage and cell-cycle changes in many tissues and organs, including the kidney. However, the underlying molecular mechanisms of fluoride-induced renal cell-cycle changes are not well understood at present. In this study, we used...

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Bibliographic Details
Main Authors: Qin Luo, Hongrui Guo, Ping Kuang, Hengmin Cui, Huidan Deng, Huan Liu, Yujiao Lu, Qin Wei, Linlin Chen, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
Sodium fluoride
G2/M phase arrest
ATM-Chk2-p53/Cdc25C signaling pathway
Proliferation
Kidney
Mice
Online Access:https://www.karger.com/Article/FullText/495899

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https://www.karger.com/Article/FullText/495899

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