Hybrid Silica-Coated PLGA Nanoparticles for Enhanced Enzyme-Based Therapeutics

Hybrid Silica-Coated PLGA Nanoparticles for Enhanced Enzyme-Based Therapeutics

Some cancer cells rely heavily on non-essential biomolecules for survival, growth, and proliferation. Enzyme based therapeutics can eliminate these biomolecules, thus specifically targeting neoplastic cells; however, enzyme therapeutics are susceptible to immune clearance, exhibit short half-lives,...

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Bibliographic Details
Main Authors: Kyle T. Gustafson, Negin Mokhtari, Elise C. Manalo, Jose Montoya Mira, Austin Gower, Ya-San Yeh, Mukanth Vaidyanathan, Sadik C. Esener, Jared M. Fischer
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
poly(lactic-co-glycolic acid)
silica
nanoparticles
enzymes
amino acid depletion
cancer
Online Access:https://www.mdpi.com/1999-4923/15/1/143

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https://www.mdpi.com/1999-4923/15/1/143

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