Predicted resistance to broadly neutralizing antibodies (bnAbs) and associated HIV-1 envelope characteristics among seroconverting adults in Botswana

Predicted resistance to broadly neutralizing antibodies (bnAbs) and associated HIV-1 envelope characteristics among seroconverting adults in Botswana

Abstract We used HIV-1C sequences to predict (in silico) resistance to 33 known broadly neutralizing antibodies (bnAbs) and evaluate the different HIV-1 Env characteristics that may affect virus neutralization. We analyzed proviral sequences from adults with documented HIV-1 seroconversion (N = 140)...

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Bibliographic Details
Main Authors: Natasha O. Moraka, Wonderful T. Choga, Marea N. Pema, Moses Kudzai Chawawa, Irene Gobe, Margaret Mokomane, Ontlametse T. Bareng, Lynette Bhebhe, Nametso Kelentse, Graceful Mulenga, Molly Pretorius Holme, Terence Mohammed, Catherine K. Koofhethile, Joseph M. Makhema, Roger Shapiro, Shahin Lockman, Sikhulile Moyo, Simani Gaseitsiwe
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-44722-2

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https://doi.org/10.1038/s41598-023-44722-2

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