Hydrochlorothiazide-induced glucose metabolism disorder is mediated by the gut microbiota via LPS-TLR4-related macrophage polarization

Hydrochlorothiazide-induced glucose metabolism disorder is mediated by the gut microbiota via LPS-TLR4-related macrophage polarization

Summary: Hydrochlorothiazide (HCTZ) is reported to impair glucose tolerance and may induce new onset of diabetes, but the pharmacomicrobiomics of the adverse effect for HCTZ remains unknown. Mice-fed HCTZ exhibited insulin resistance and impaired glucose tolerance. By using FMT and antibiotic cockta...

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Bibliographic Details
Main Authors: Jian-Quan Luo, Huan Ren, Man-Yun Chen, Qing Zhao, Nian Yang, Qian Liu, Yong-Chao Gao, Hong-Hao Zhou, Wei-Hua Huang, Wei Zhang
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:iScience
Subjects:
Biological sciences
Molecular physiology
Immunology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223012075

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223012075

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