Emergence of ceftazidime-avibactam resistance due to a novel blaKPC-2 mutation during treatment of carbapenem-resistant Klebsiella pneumoniae infections

Objective: Klebsiella pneumoniae carbapenemase (KPC)-producing K.pneumoniae has represented a serious health problem in worldwide. The resistance to ceftazidime-avibactam (CAZ-AVI) began to emerge since its approval in 2015. We aim to explore the resistance mechanism of CAZ-AVI. Methods: Phenotypic...

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Bibliographic Details
Main Authors: Quanfeng Liao, Jin Deng, Yu Feng, Weili Zhang, Siying Wu, Ya Liu, Huijuan Che, Yi Xie
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Journal of Infection and Public Health
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1876034122000855