Early pneumococcal clearance in mice induced by systemic immunization with recombinant BCG PspA-PdT prime and protein boost correlates with cellular and humoral immune response in bronchoalveolar fluids (BALF)

An effective immunological response in the lungs during a pneumococcal infection is a key factor to the bacteria clearance and prevention of sepsis. In order to develop broad-range pneumococcal vaccines several pneumococcal proteins and strong adjuvants have been investigated. Previously, we constru...

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Bibliographic Details
Main Authors: Cibelly Goulart, Dunia Rodriguez, Alex I. Kanno, José Lourenço S.C. Silva, Luciana C.C. Leite
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Vaccine: X
Online Access:http://www.sciencedirect.com/science/article/pii/S2590136219300506