Mutant p53-microRNA-200c-ZEB2-Axis-Induced CPT1C Elevation Contributes to Metabolic Reprogramming and Tumor Progression in Basal-Like Breast Cancers

Mutant p53-microRNA-200c-ZEB2-Axis-Induced CPT1C Elevation Contributes to Metabolic Reprogramming and Tumor Progression in Basal-Like Breast Cancers

TP53 is mutated in more than 80% of basal-like breast cancers (BLBCs). BLBCs with TP53 mutation are usually high-grade and have worse responses to chemotherapy, leading to poor clinical outcomes. Wild-type p53 (WTp53) is well-accepted to promote fatty acid oxidation (FAO); however, in this study, we...

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Bibliographic Details
Main Authors: Chen-Yun Wang, Cing-Hong Wang, Ru-Tsun Mai, Ting-Wen Chen, Chia-Wei Li, Chi-Hong Chao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
mutant p53
tumor progression
CPT1C
FAO
basal-like breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.940402/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.940402/full

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