Insight into the Inhibitory Mechanism of Embryonic Ectoderm Development Subunit by Triazolopyrimidine Derivatives as Inhibitors through Molecular Dynamics Simulation

Inhibition of the Embryonic Ectoderm Development (EED) subunit in <b>Polycomb Repressive Complex 2</b> (PRC2) can inhibit tumor growth. In this paper, we selected six experimentally designed EED competitive Inhibitors of the triazolopyrimidine derivatives class. We investigated the diffe...

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Bibliographic Details
Main Authors: Jianan Ju, Hao Zhang, Shanshan Guan, Chang Liu, Juan Du, Xiaoli Shen, Song Wang
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/28/24/7997