Rooibos Flavonoids Inhibit the Activity of Key Adrenal Steroidogenic Enzymes, Modulating Steroid Hormone Levels in H295R Cells

Rooibos Flavonoids Inhibit the Activity of Key Adrenal Steroidogenic Enzymes, Modulating Steroid Hormone Levels in H295R Cells

Major rooibos flavonoids—dihydrochalcones, aspalathin and nothofagin, flavones—orientin and vitexin, and a flavonol, rutin, were investigated to determine their influence on the activity of adrenal steroidogenic enzymes, 3β-hydroxysteroid dehydrogenase (3βHSD2) and cytochrome P450 (P450) enzymes, P4...

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Bibliographic Details
Main Authors: Lindie Schloms, Amanda C. Swart
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:Molecules
Subjects:
Aspalathus linearis
rooibos polyphenols
adrenal steroidogenesis
cytochrome P450 enzymes
UPLC-MS/MS
adrenal H295R cells
cortisol
metabolic disorder
structure-activity relationship
stress
Online Access:http://www.mdpi.com/1420-3049/19/3/3681

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http://www.mdpi.com/1420-3049/19/3/3681

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