Reduced OPA1, Mitochondrial Fragmentation and Increased Susceptibility to Apoptosis in Granular Corneal Dystrophy Type 2 Corneal Fibroblasts

Reduced OPA1, Mitochondrial Fragmentation and Increased Susceptibility to Apoptosis in Granular Corneal Dystrophy Type 2 Corneal Fibroblasts

The progressive degeneration of granular corneal dystrophy type 2 (GCD2) corneal fibroblasts is associated with altered mitochondrial function, but the underlying mechanisms are incompletely understood. We investigated whether an imbalance of mitochondrial dynamics contributes to mitochondrial dysfu...

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Bibliographic Details
Main Authors: Seung-Il Choi, Ga-Hyun Lee, Jong-Hwan Woo, Ikhyun Jun, Eung Kweon Kim
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Genes
Subjects:
mitochondria
OPA1
NRF1
PGC1α
fission and fusion
corneal fibroblasts
Online Access:https://www.mdpi.com/2073-4425/14/3/566

Internet

https://www.mdpi.com/2073-4425/14/3/566

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