Reduced OPA1, Mitochondrial Fragmentation and Increased Susceptibility to Apoptosis in Granular Corneal Dystrophy Type 2 Corneal Fibroblasts

Reduced OPA1, Mitochondrial Fragmentation and Increased Susceptibility to Apoptosis in Granular Corneal Dystrophy Type 2 Corneal Fibroblasts

The progressive degeneration of granular corneal dystrophy type 2 (GCD2) corneal fibroblasts is associated with altered mitochondrial function, but the underlying mechanisms are incompletely understood. We investigated whether an imbalance of mitochondrial dynamics contributes to mitochondrial dysfu...

Full description

Bibliographic Details
Main Authors: Seung-Il Choi, Ga-Hyun Lee, Jong-Hwan Woo, Ikhyun Jun, Eung Kweon Kim
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Genes
Subjects:
mitochondria
OPA1
NRF1
PGC1α
fission and fusion
corneal fibroblasts
Online Access:https://www.mdpi.com/2073-4425/14/3/566

Similar Items

Similar Items