Inflammation-mediated fibroblast activation and immune dysregulation in collagen VII-deficient skin

Inflammation-mediated fibroblast activation and immune dysregulation in collagen VII-deficient skin

Inflammation is known to play a critical role in all stages of tumorigenesis; however, less is known about how it predisposes the tissue microenvironment preceding tumor formation. Recessive dystrophic epidermolysis bullosa (RDEB), a skin-blistering disease secondary to COL7A1 mutations and associat...

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Bibliographic Details
Main Authors: Morgan Anderson-Crannage, Alex M. Ascensión, Olga Ibanez-Solé, Hongwen Zhu, Edo Schaefer, Darcy Ottomanelli, Bruno Hochberg, Jian Pan, Wen Luo, Meijuan Tian, Yaya Chu, Mitchell S. Cairo, Ander Izeta, Yanling Liao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
epidermolysis bullosa
inflammation
immune suppression
dermal microenvironment
fibroblast activation
interleukin-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1211505/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1211505/full

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