Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis

Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis

Down syndrome (trisomy 21) neurons display an increased rate of apoptosis in vitro. The genes on chromosome 21 that mediate this increased cell death remain to be elucidated. Here we show that the chromosome 21 transcription factor Ets2, a gene that is overexpressed in Down syndrome, is expressed in...

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Bibliographic Details
Main Authors: E.J Wolvetang, O.M Bradfield, T Hatzistavrou, P.J Crack, J Busciglio, I Kola, P.J Hertzog
Format: Article
Language:English
Published: Elsevier 2003-12-01
Series:Neurobiology of Disease
Subjects:
Ets transcription factor
Apoptosis
Down syndrome
β-APP
Alzheimer's disease
Ets2
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103001074

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http://www.sciencedirect.com/science/article/pii/S0969996103001074

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