Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis
Down syndrome (trisomy 21) neurons display an increased rate of apoptosis in vitro. The genes on chromosome 21 that mediate this increased cell death remain to be elucidated. Here we show that the chromosome 21 transcription factor Ets2, a gene that is overexpressed in Down syndrome, is expressed in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2003-12-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996103001074 |
| _version_ | 1819119488688193536 |
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| author | E.J Wolvetang O.M Bradfield T Hatzistavrou P.J Crack J Busciglio I Kola P.J Hertzog |
| author_facet | E.J Wolvetang O.M Bradfield T Hatzistavrou P.J Crack J Busciglio I Kola P.J Hertzog |
| author_sort | E.J Wolvetang |
| collection | DOAJ |
| description | Down syndrome (trisomy 21) neurons display an increased rate of apoptosis in vitro. The genes on chromosome 21 that mediate this increased cell death remain to be elucidated. Here we show that the chromosome 21 transcription factor Ets2, a gene that is overexpressed in Down syndrome, is expressed in neurons, and that moderate overexpression of Ets2 leads to increased apoptosis of primary neuronal cultures from Ets2 tg mice that involves activation of caspase-3. Our data therefore suggest that overexpression of ETS2 may contribute to the increased rate of apoptosis of neurons in Down syndrome. |
| first_indexed | 2024-12-22T06:05:34Z |
| format | Article |
| id | doaj.art-34e1ff2b1c2c42ea8e9748eda01ac032 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-22T06:05:34Z |
| publishDate | 2003-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-34e1ff2b1c2c42ea8e9748eda01ac0322022-12-21T18:36:25ZengElsevierNeurobiology of Disease1095-953X2003-12-01143349356Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosisE.J Wolvetang0O.M Bradfield1T Hatzistavrou2P.J Crack3J Busciglio4I Kola5P.J Hertzog6Centre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Monash Medical Center, 246 Clayton Road, Clayton 3168, Australia; Department of Neuroscience, MC-3401, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USACentre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Monash Medical Center, 246 Clayton Road, Clayton 3168, Australia; Department of Neuroscience, MC-3401, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USACentre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Monash Medical Center, 246 Clayton Road, Clayton 3168, Australia; Department of Neuroscience, MC-3401, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USACentre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Monash Medical Center, 246 Clayton Road, Clayton 3168, Australia; Department of Neuroscience, MC-3401, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USACentre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Monash Medical Center, 246 Clayton Road, Clayton 3168, Australia; Department of Neuroscience, MC-3401, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USACentre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Monash Medical Center, 246 Clayton Road, Clayton 3168, Australia; Department of Neuroscience, MC-3401, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USACentre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Monash Medical Center, 246 Clayton Road, Clayton 3168, Australia; Department of Neuroscience, MC-3401, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USADown syndrome (trisomy 21) neurons display an increased rate of apoptosis in vitro. The genes on chromosome 21 that mediate this increased cell death remain to be elucidated. Here we show that the chromosome 21 transcription factor Ets2, a gene that is overexpressed in Down syndrome, is expressed in neurons, and that moderate overexpression of Ets2 leads to increased apoptosis of primary neuronal cultures from Ets2 tg mice that involves activation of caspase-3. Our data therefore suggest that overexpression of ETS2 may contribute to the increased rate of apoptosis of neurons in Down syndrome.http://www.sciencedirect.com/science/article/pii/S0969996103001074Ets transcription factorApoptosisDown syndromeβ-APPAlzheimer's diseaseEts2 |
| spellingShingle | E.J Wolvetang O.M Bradfield T Hatzistavrou P.J Crack J Busciglio I Kola P.J Hertzog Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis Neurobiology of Disease Ets transcription factor Apoptosis Down syndrome β-APP Alzheimer's disease Ets2 |
| title | Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis |
| title_full | Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis |
| title_fullStr | Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis |
| title_full_unstemmed | Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis |
| title_short | Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis |
| title_sort | overexpression of the chromosome 21 transcription factor ets2 induces neuronal apoptosis |
| topic | Ets transcription factor Apoptosis Down syndrome β-APP Alzheimer's disease Ets2 |
| url | http://www.sciencedirect.com/science/article/pii/S0969996103001074 |
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