Activation of the AMPK-SIRT1 pathway contributes to protective effects of Salvianolic acid A against lipotoxicity in hepatocytes and NAFLD in mice

Activation of the AMPK-SIRT1 pathway contributes to protective effects of Salvianolic acid A against lipotoxicity in hepatocytes and NAFLD in mice

Background: Salvianolic acid A (Sal A), a natural polyphenol compound extracted from Radix Salvia miltiorrhiza (known as Danshen in China), possesses a variety of potential pharmacological activities. The aim of this study is to determine mechanisms of hepatoprotective effects of Sal A against lipot...

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Bibliographic Details
Main Authors: Songtao Li, Qianyu Qian, Na Ying, Jianfei Lai, Luyan Feng, Sitong Zheng, Fusheng Jiang, Qing Song, Hui Chai, Xiaobing Dou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Pharmacology
Subjects:
salvianolic acid A
adenosine monophosphate activated protein kinase
sirtuin 1
lipotoxicity
non-alcoholic fatty liver disease
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.560905/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.560905/full

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