Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer

Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer

Abstract Background Dysregulation of hedgehog pathway is observed in numerous cancers. Relevance of hedgehog pathway genes in cancer cohort and inhibition of its downstream effector (GLI1) towards metastasis in cell lines are explored in the study. Method One hundred fifty fresh tumours of breast ca...

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Bibliographic Details
Main Authors: Syeda Kiran Riaz, Jahangir Sarwar Khan, Syed Tahir Abbas Shah, Fen Wang, Lin Ye, Wen G. Jiang, Muhammad Faraz Arshad Malik
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Cell Communication and Signaling
Subjects:
Breast cancer
Hedgehog pathway
SHH
DHH
GLI1
GANT61
Online Access:http://link.springer.com/article/10.1186/s12964-017-0213-y

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http://link.springer.com/article/10.1186/s12964-017-0213-y

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