Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor

Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor

The glioma-associated family of transcription factors (GLI) have emerged as a promising therapeutic target for a variety of human cancers. In particular, GLI1 plays a central role as a transcriptional regulator for multiple oncogenic signaling pathways, including the hedgehog (Hh) signaling pathway....

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Bibliographic Details
Main Authors: Radha Charan Dash, Jiachen Wen, Angela M. Zaino, Shana R. Morel, Lianne Q. Chau, Robert J. Wechsler-Reya, M. Kyle Hadden
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
GLI1
cancer structure-based virtual screening
Computational Medicinal Chemistry
Zinc finger
GANT61
Molecular Dynamics
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521000048

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http://www.sciencedirect.com/science/article/pii/S2372770521000048

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