Hepatocellular carcinoma cells remodel the pro-metastatic tumour microenvironment through recruitment and activation of fibroblasts via paracrine Egfl7 signaling

Hepatocellular carcinoma cells remodel the pro-metastatic tumour microenvironment through recruitment and activation of fibroblasts via paracrine Egfl7 signaling

Abstract Background The tumour microenvironment consists of a complex and dynamic milieu of cancer cells, including tumour-associated stromal cells (leukocytes, fibroblasts, vascular cells, etc.) and their extracellular products. During invasion and metastasis, cancer cells actively remodel the tumo...

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Bibliographic Details
Main Authors: Bo Sun, Xiong Lei, Momo Cao, Yiming Li, Lian-Yue Yang
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Cell Communication and Signaling
Subjects:
Hepatocellular carcinoma
Tumour microenvironment
Cancer-associated fibroblasts
EGF like domain multiple 7
Integrin ανβ3
Online Access:https://doi.org/10.1186/s12964-023-01200-6

Internet

https://doi.org/10.1186/s12964-023-01200-6

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