Breaking Therapy Resistance: An Update on Oncolytic Newcastle Disease Virus for Improvements of Cancer Therapy

Breaking Therapy Resistance: An Update on Oncolytic Newcastle Disease Virus for Improvements of Cancer Therapy

Resistance to therapy is a major obstacle to cancer treatment. It may exist from the beginning, or it may develop during therapy. The review focusses on oncolytic Newcastle disease virus (NDV) as a biological agent with potential to break therapy resistance. This avian virus combines, upon inoculati...

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Bibliographic Details
Main Authors: Volker Schirrmacher, Stefaan van Gool, Wilfried Stuecker
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Biomedicines
Subjects:
NDV
viral oncolysis
immunogenic cell death
type I interferon
dendritic cells
active-specific immunotherapy
bispecific antibodies
gene therapy
checkpoint inhibition
T cell costimulation
RIG-I
IFNAR
Online Access:https://www.mdpi.com/2227-9059/7/3/66

Internet

https://www.mdpi.com/2227-9059/7/3/66

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