VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice

VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice

Silicosis is a diffuse fibrotic lung disease in which excessive inflammatory responses are triggered by silica exposure. Pyroptosis, a pro-inflammatory mode of programmed cell death, is mediated by gasdermin and may play a pivotal role in the development of silicosis. The caspase-1 inhibitor, VX-765...

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Bibliographic Details
Main Authors: Huihui Tao, Hui Zhao, Aowei Mo, Luocheng Shao, Deyong Ge, Jiale Liu, Wenjian Hu, Keyi Xu, Qianqian Ma, Wenfeng Wang, Wenyang Wang, Hangbing Cao, Min Mu, Xinrong Tao, Jianhua Wang
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
VX-765
Alveolar macrophages
Caspase-1
Pyroptosis
Silica exposure
Silicosis
Online Access:http://www.sciencedirect.com/science/article/pii/S014765132201199X

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http://www.sciencedirect.com/science/article/pii/S014765132201199X

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