KSR induces RAS‐independent MAPK pathway activation and modulates the efficacy of KRAS inhibitors

KSR induces RAS‐independent MAPK pathway activation and modulates the efficacy of KRAS inhibitors

The kinase suppressor of rat sarcoma (RAS) proteins (KSR1 and KSR2) have long been considered as scaffolding proteins required for optimal mitogen‐activated protein kinase (MAPK) pathway signalling. However, recent evidence suggests that they play a more complex role within this pathway. Here, we de...

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Bibliographic Details
Main Authors: Guillem Paniagua, Harrys K.C. Jacob, Oksana Brehey, Sara García‐Alonso, Carmen G. Lechuga, Tirso Pons, Monica Musteanu, Carmen Guerra, Matthias Drosten, Mariano Barbacid
Format: Article
Language:English
Published: Wiley 2022-09-01
Series:Molecular Oncology
Subjects:
ATP binding
KRASG12C
MAPK pathway
RAS‐independent proliferation
resistance
sotorasib
Online Access:https://doi.org/10.1002/1878-0261.13213

Internet

https://doi.org/10.1002/1878-0261.13213

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