Onset of Senescence and Steatosis in Hepatocytes as a Consequence of a Shift in the Diacylglycerol/Ceramide Balance at the Plasma Membrane

Ceramide and diacylglycerol (DAG) are bioactive lipids and mediate many cellular signaling pathways. Sphingomyelin synthase (SMS) is the single metabolic link between the two, while SMS2 is the only SMS form located at the plasma membrane. SMS2 functions were investigated in HepG2 cell lines stably...

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Main Authors: Gergana Deevska, Patrick P. Dotson, Mihail Mitov, D. Allan Butterfield, Mariana Nikolova-Karakashian
פורמט: Article
שפה:English
יצא לאור: MDPI AG 2021-05-01
סדרה:Cells
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גישה מקוונת:https://www.mdpi.com/2073-4409/10/6/1278