New quinoline-based triazole hybrid analogs as effective inhibitors of α-amylase and α-glucosidase: Preparation, in vitro evaluation, and molecular docking along with in silico studies

New quinoline-based triazole hybrid analogs as effective inhibitors of α-amylase and α-glucosidase: Preparation, in vitro evaluation, and molecular docking along with in silico studies

The 7-quinolinyl-bearing triazole analogs were synthesized (1d–19d) and further assessed in vitro for their inhibitory profile against α-amylase andα-glucosidase. The entire analogs showed a diverse range of activities having IC50 values between 0.80 ± 0.05 µM to 40.20 ± 0.70 µM (α-amylase) and 1.20...

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Bibliographic Details
Main Authors: Yousaf Khan, Shahid Iqbal, Mazloom Shah, Aneela Maalik, Rafaqat Hussain, Shoaib Khan, Imran Khan, Rami Adel Pashameah, Eman Alzahrani, Abd-ElAziem Farouk, Mohammed Issa Alahmdi, Hisham S. M. Abd-Rabboh
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Chemistry
Subjects:
quinoline
triazole
α-amylase enzymes
α-glucosidase enzymes
molecular docking
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.995820/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.995820/full

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