New quinoline-based triazole hybrid analogs as effective inhibitors of α-amylase and α-glucosidase: Preparation, in vitro evaluation, and molecular docking along with in silico studies
The 7-quinolinyl-bearing triazole analogs were synthesized (1d–19d) and further assessed in vitro for their inhibitory profile against α-amylase andα-glucosidase. The entire analogs showed a diverse range of activities having IC50 values between 0.80 ± 0.05 µM to 40.20 ± 0.70 µM (α-amylase) and 1.20...
المؤلفون الرئيسيون: | , , , , , , , , , , , |
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التنسيق: | مقال |
اللغة: | English |
منشور في: |
Frontiers Media S.A.
2022-09-01
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سلاسل: | Frontiers in Chemistry |
الموضوعات: | |
الوصول للمادة أونلاين: | https://www.frontiersin.org/articles/10.3389/fchem.2022.995820/full |