Human neural stem cells restore spatial memory in a transgenic Alzheimer’s disease mouse model by an immunomodulating mechanism

Human neural stem cells restore spatial memory in a transgenic Alzheimer’s disease mouse model by an immunomodulating mechanism

IntroductionStem cells are a promising therapeutic in Alzheimer’s disease (AD) given the complex pathophysiologic pathways involved. However, the therapeutic mechanisms of stem cells remain unclear. Here, we used spatial transcriptomics to elucidate therapeutic mechanisms of human neural stem cells...

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Bibliographic Details
Main Authors: Kevin S. Chen, Mohamed H. Noureldein, Lisa M. McGinley, John M. Hayes, Diana M. Rigan, Jacquelin F. Kwentus, Shayna N. Mason, Faye E. Mendelson, Masha G. Savelieff, Eva L. Feldman
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
cell communication
disease-associated microglia
immunomodulation
microglia
neural stem cell
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1306004/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2023.1306004/full

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