Disruption of C/EBPβ-Clec7a axis exacerbates neuroinflammatory injury via NLRP3 inflammasome-mediated pyroptosis in experimental neuropathic pain

Disruption of C/EBPβ-Clec7a axis exacerbates neuroinflammatory injury via NLRP3 inflammasome-mediated pyroptosis in experimental neuropathic pain

Abstract Background Growing evidence shows that C-Type Lectin Domain Containing 7A (Clec7a) may be involved into neuroinflammatory injury of various neurological diseases. However, its roles in neuropathic pain remain unclear. Methods A chronic constriction injury (CCI) rat model was constructed, an...

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Bibliographic Details
Main Authors: Dan Wu, Yanqiong Zhang, Chunhui Zhao, Qiuyue Li, Junhong Zhang, Jiaxin Han, Zhijian Xu, Junfang Li, Yan Ma, Ping Wang, Haiyu Xu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Translational Medicine
Subjects:
C/EBPβ-Clec7a axis
Neuroinflammation
Neuropathic Pain
NLRP3 Inflammasome-mediated Pyroptosis
Online Access:https://doi.org/10.1186/s12967-022-03779-9

Internet

https://doi.org/10.1186/s12967-022-03779-9

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