Xanthohumol ameliorates Diet-Induced Liver Dysfunction via Farnesoid X Receptor-Dependent and Independent Signaling

Xanthohumol ameliorates Diet-Induced Liver Dysfunction via Farnesoid X Receptor-Dependent and Independent Signaling

The farnesoid X receptor (FXR) plays a critical role in the regulation of lipid and bile acid (BA) homeostasis. Hepatic FXR loss results in lipid and BA accumulation, and progression from hepatic steatosis to nonalcoholic steatohepatitis (NASH). This study aimed to evaluate the effects of xanthohumo...

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Bibliographic Details
Main Authors: Ines L. Paraiso, Thai Q. Tran, Armando Alcazar Magana, Payel Kundu, Jaewoo Choi, Claudia S. Maier, Gerd Bobe, Jacob Raber, Chrissa Kioussi, Jan F. Stevens
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
nonalcoholic fatty liver disease
farnesoid X receptor
bile acids
lipid metabolism
xanthohumol
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.643857/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.643857/full

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