Intraocular DHODH-inhibitor PP-001 suppresses relapsing experimental uveitis and cytokine production of human lymphocytes, but not of RPE cells

Intraocular DHODH-inhibitor PP-001 suppresses relapsing experimental uveitis and cytokine production of human lymphocytes, but not of RPE cells

Abstract Background Uveitis is a potentially blinding inflammatory disease of the inner eye with a high unmet need for new therapeutic interventions. Here, we wanted to investigate the suppressive effect of the intraocular application of the small molecule dihydroorotate dehydrogenase (DHODH)-inhibi...

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Bibliographic Details
Main Authors: Maria Diedrichs-Möhring, Sandy Niesik, Claudia S. Priglinger, Stephan R. Thurau, Franz Obermayr, Stefan Sperl, Gerhild Wildner
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Neuroinflammation
Subjects:
Experimental autoimmune uveitis
Rat model
DHODH-inhibitor
Lymphocytes
RPE cells
Cytokines
Online Access:http://link.springer.com/article/10.1186/s12974-018-1088-6

Internet

http://link.springer.com/article/10.1186/s12974-018-1088-6

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