A Multifocal Pediatric Papillary Thyroid Carcinoma (PTC) Harboring the <i>AGK-BRAF</i> and <i>RET/PTC3</i> Fusion in a Mutually Exclusive Pattern Reveals Distinct Levels of Genomic Instability and Nuclear Organization

A Multifocal Pediatric Papillary Thyroid Carcinoma (PTC) Harboring the <i>AGK-BRAF</i> and <i>RET/PTC3</i> Fusion in a Mutually Exclusive Pattern Reveals Distinct Levels of Genomic Instability and Nuclear Organization

The spectrum and incidence of gene fusions in papillary thyroid carcinoma (PTC) can differ significantly depending on the age of onset, histological subtype or radiation exposure history. In sporadic pediatric PTC, <i>RET/PTC1-3</i> and <i>AGK-BRAF</i> fusions are common gene...

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Bibliographic Details
Main Authors: Luiza Sisdelli, Maria Isabel V. Cordioli, Fernanda Vaisman, Osmar Monte, Carlos A. Longui, Adriano N. Cury, Monique O. Freitas, Aline Rangel-Pozzo, Sabine Mai, Janete M. Cerutti
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Biology
Subjects:
papillary thyroid carcinoma
pediatric thyroid cancer
nuclear architecture
super-resolution microscope
AGK-BRAF
RET/PTC
Online Access:https://www.mdpi.com/2079-7737/10/2/125

Internet

https://www.mdpi.com/2079-7737/10/2/125

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