Spontaneous Immortalization of Clinically Normal Colon-Derived Fibroblasts from a Familial Adenomatous Polyposis Patient

Spontaneous Immortalization of Clinically Normal Colon-Derived Fibroblasts from a Familial Adenomatous Polyposis Patient

Normal human diploid cells do not spontaneously immortalize in culture, but instead enter replicative senescence after a finite number of population doublings. Ablation of key checkpoint arrest or cancersuppressor genes, through dominantly inherited germline mutation (p53+/-, Li-Fraumeni) or viral o...

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Bibliographic Details
Main Authors: Nicholas R. Forsyth, Carmela P. Morales, Shirish Damle, Bruce Boman, Woodring E. Wright, Levy Kopelovich, Jerry W. Shay
Format: Article
Language:English
Published: Elsevier 2004-05-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Adenomatous polyposis coli
familial adenomatous polyposis
spontaneous immortalization
telomerase
telomere
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558604800733

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http://www.sciencedirect.com/science/article/pii/S1476558604800733

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