Distinct motor impairments of dopamine D1 and D2 receptor knockout mice revealed by three types of motor behavior

Distinct motor impairments of dopamine D1 and D2 receptor knockout mice revealed by three types of motor behavior

Both D1R and D2R knock out (KO) mice of the major dopamine receptors show significant motor impairments. However, there are some discrepant reports, which may be due to the differences in genetic background and experimental procedures. In addition, only few studies directly compared the motor perfo...

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Bibliographic Details
Main Authors: Toru eNakamura, Asako eSato, Takashi eKitsukawa, Toshihiko eMomiyama, Tetsuo eYamamori, Toshikuni eSasaoka
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Integrative Neuroscience
Subjects:
Motor Activity
Dopamine receptor
behavioral task
congenic knockout mice
skilled motor performance
rota-rod
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnint.2014.00056/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnint.2014.00056/full

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