Novel preclinical model for CDKL5 deficiency disorder

Novel preclinical model for CDKL5 deficiency disorder

Cyclin-dependent kinase-like-5 (CDKL5) deficiency disorder (CDD) is a severe X-linked neurodegenerative disease characterised by early-onset epileptic seizures, low muscle tone, progressive intellectual disability and severe motor function. CDD affects ∼1 in 60,000 live births, with many patients ex...

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Bibliographic Details
Main Authors: Rita J. Serrano, Clara Lee, Alon M. Douek, Jan Kaslin, Robert J. Bryson-Richardson, Tamar E. Sztal
Format: Article
Language:English
Published: The Company of Biologists 2022-03-01
Series:Disease Models & Mechanisms
Subjects:
cdkl5 deficiency disorder
motor neurons
seizure
locomotion
microcephaly
zebrafish
Online Access:http://dmm.biologists.org/content/15/3/dmm049094

Internet

http://dmm.biologists.org/content/15/3/dmm049094

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