Histone Deacetylase Inhibitory Activity and Antiproliferative Potential of New [6]-Shogaol Derivatives

Histone Deacetylase Inhibitory Activity and Antiproliferative Potential of New [6]-Shogaol Derivatives

Twenty newly synthesized derivatives of [6]-shogaol (<b>4</b>) were tested for inhibitory activity against histone deacetylases. All derivatives showed moderate to good histone deacetylase inhibition at 100 µM with a slightly lower potency than the lead compound. Most potent inhibitors a...

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Bibliographic Details
Main Authors: Chanokbhorn Phaosiri, Chavi Yenjai, Thanaset Senawong, Gulsiri Senawong, Somprasong Saenglee, La-or Somsakeesit, Pakit Kumboonma
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
ginger
<i>Zingiber officinale</i>
[6]-shogaol derivatives
anticancer
molecular docking
Online Access:https://www.mdpi.com/1420-3049/27/10/3332

Internet

https://www.mdpi.com/1420-3049/27/10/3332

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