Ubiquitin-Specific Protease 14 Negatively Regulates Toll-Like Receptor 4-Mediated Signaling and Autophagy Induction by Inhibiting Ubiquitination of TAK1-Binding Protein 2 and Beclin 1

Ubiquitin-Specific Protease 14 Negatively Regulates Toll-Like Receptor 4-Mediated Signaling and Autophagy Induction by Inhibiting Ubiquitination of TAK1-Binding Protein 2 and Beclin 1

Ubiquitin-specific protease 14 (USP14), one of three proteasome-associated deubiquitinating enzymes, has multifunctional roles in cellular context. Here, we report a novel molecular mechanism and function of USP14 in regulating autophagy induction and nuclear factor-kappa B (NF-κB) activation induce...

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Bibliographic Details
Main Authors: Yoon Min, Sena Lee, Mi-Jeong Kim, Eunyoung Chun, Ki-Young Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
autophagy
Beclin 1
toll-like receptor 4
tumor necrosis factor receptor-associated factor 6
TAK1-binding protein 2
ubiquitination
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01827/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01827/full

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