Emerging epigenetic therapeutics for myeloid leukemia: modulating demethylase activity with ascorbate

The past decade has seen a proliferation of drugs that target epigenetic pathways. Many of these drugs were developed to treat acute myeloid leukemia, a condition in which dysregulation of the epigenetic landscape is well established. While these drugs have shown promise, critical issues persist. S...

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Bibliographic Details
Main Authors: Andrew B. Das, Carlos C. Smith-Díaz, Margreet C.M. Vissers
Format: Article
Language:English
Published: Ferrata Storti Foundation 2020-10-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/10064