Extended Interactions between HIV-1 Viral RNA and tRNA<sup>Lys3</sup> Are Important to Maintain Viral RNA Integrity

Extended Interactions between HIV-1 Viral RNA and tRNA<sup>Lys3</sup> Are Important to Maintain Viral RNA Integrity

The reverse transcription of the human immunodeficiency virus 1 (HIV-1) initiates upon annealing of the 3′-18-nt of tRNA<sup>Lys3</sup> onto the primer binding site (PBS) in viral RNA (vRNA). Additional intermolecular interactions between tRNA<sup>Lys3</sup> and vRNA have bee...

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Bibliographic Details
Main Authors: Thomas Gremminger, Zhenwei Song, Juan Ji, Avery Foster, Kexin Weng, Xiao Heng
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
HIV-1 PBS
tRNA<sup>Lys3</sup>
reverse transcription
degradation
genomic RNA integrity
Online Access:https://www.mdpi.com/1422-0067/22/1/58

Internet

https://www.mdpi.com/1422-0067/22/1/58

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