FRAP analysis of chromatin looseness in mouse zygotes that allows full-term development.

Chromatin looseness, which can be analyzed by fluorescence recovery after photobleaching (FRAP) using eGFP-tagged core histone proteins, is an important index of the differentiation potential of blastomere cells and embryonic stem cells. Whether chromatin looseness is a reliable index of the develop...

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Bibliographic Details
Main Authors: Masatoshi Ooga, Teruhiko Wakayama
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5440048?pdf=render