Heteronemin, a Marine Sesterterpenoid-Type Metabolite, Induces Apoptosis in Prostate LNcap Cells via Oxidative and ER Stress Combined with the Inhibition of Topoisomerase II and Hsp90

Heteronemin, a Marine Sesterterpenoid-Type Metabolite, Induces Apoptosis in Prostate LNcap Cells via Oxidative and ER Stress Combined with the Inhibition of Topoisomerase II and Hsp90

Heteronemin, a marine sesterterpenoid-type natural product, possesses diverse bioactivities, especially antitumor effect. Accumulating evidence shows that heteronemin may act as a potent anticancer agent in clinical therapy. To fully understand the antitumor mechanism of heteronemin, we further expl...

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Bibliographic Details
Main Authors: Man-Gang Lee, Yi-Chang Liu, Yi-Lun Lee, Mohamed El-Shazly, Kuei-Hung Lai, Shou-Ping Shih, Seng-Chung Ke, Ming-Chang Hong, Ying-Chi Du, Juan-Cheng Yang, Ping-Jyun Sung, Zhi-Hong Wen, Mei-Chin Lu
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Marine Drugs
Subjects:
antitumor
apoptosis
autophagy
ER stress
heteronemin
Hsp90
topoisomerase II catalytic inhibitor
Online Access:http://www.mdpi.com/1660-3397/16/6/204

Internet

http://www.mdpi.com/1660-3397/16/6/204

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