ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker

ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker

Abstract The evolution of coronaviruses, such as SARS-CoV-2, makes broad-spectrum coronavirus preventional or therapeutical strategies highly sought after. Here we report a human angiotensin-converting enzyme 2 (ACE2)-targeting monoclonal antibody, 3E8, blocked the S1-subunits and pseudo-typed virus...

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Bibliographic Details
Main Authors: Yuning Chen, Ya-Nan Zhang, Renhong Yan, Guifeng Wang, Yuanyuan Zhang, Zhe-Rui Zhang, Yaning Li, Jianxia Ou, Wendi Chu, Zhijuan Liang, Yongmei Wang, Yi-Li Chen, Ganjun Chen, Qi Wang, Qiang Zhou, Bo Zhang, Chunhe Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00740-y

Internet

https://doi.org/10.1038/s41392-021-00740-y

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