Harnessing radiotherapy-induced NK-cell activity by combining DNA damage–response inhibition and immune checkpoint blockade

Harnessing radiotherapy-induced NK-cell activity by combining DNA damage–response inhibition and immune checkpoint blockade

Background Despite therapeutic gains from immune checkpoint inhibitors (ICI) in many tumor types, new strategies are needed to extend treatment benefits, especially in patients failing to mount effective antitumor T-cell responses. Radiation and drug therapies can profoundly affect the tumor immune...

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Bibliographic Details
Main Authors: Simon Smith, Hormas Ghadially, Kevin J Harrington, Alan A Melcher, Isla Leslie, Eva Crespo-Rodriguez, Galabina Bozhanova, Emmanuel C Patin, Harriet Whittock, Martin McLaughlin, Malin Pedersen, James Harper, Pablo Nenclares, Heba Soliman, Magnus T Dillon, Lorna Grove, Davina Northcote, Holly Baldock, Gabriella Baker, Joan Kyula, Jeane Guevara
Format: Article
Language:English
Published: BMJ Publishing Group 2022-03-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/10/3/e004306.full

Internet

https://jitc.bmj.com/content/10/3/e004306.full

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