Francisella tularensis harvests nutrients derived via ATG5-independent autophagy to support intracellular growth.
Francisella tularensis is a highly virulent intracellular pathogen that invades and replicates within numerous host cell types including macrophages, hepatocytes and pneumocytes. By 24 hours post invasion, F. tularensis replicates up to 1000-fold in the cytoplasm of infected cells. To achieve such r...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-08-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC3744417?pdf=render |