Necroptosis enhances ‘don’t eat me’ signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis

Necroptosis enhances ‘don’t eat me’ signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with dismal prognosis due to distant metastasis, even in the early stage. Using RNA sequencing and multiplex immunofluorescence, here we find elevated expression of mixed lineage kinase domain-like pseudo-kinase (MLKL) and enha...

Full description

Bibliographic Details
Main Authors: Cheng-Yu Liao, Ge Li, Feng-Ping Kang, Cai-Feng Lin, Cheng-Ke Xie, Yong-Ding Wu, Jian-Fei Hu, Hong-Yi Lin, Shun-Cang Zhu, Xiao-Xiao Huang, Jian-Lin Lai, Li-Qun Chen, Yi Huang, Qiao-Wei Li, Long Huang, Zu-Wei Wang, Yi-Feng Tian, Shi Chen
Format: Article
Language:English
Published: Nature Portfolio 2024-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-50450-6

Internet

https://doi.org/10.1038/s41467-024-50450-6

Similar Items