Low Shear Stress Increases Recombinant Protein Production and High Shear Stress Increases Apoptosis in Human Cells

Low Shear Stress Increases Recombinant Protein Production and High Shear Stress Increases Apoptosis in Human Cells

Summary: Human embryonic kidney cells HEK293 can be used for the production of therapeutic glycoproteins requiring human post-translational modifications. High cell density perfusion processes are advantageous for such production but are challenging due to the shear sensitivity of HEK293 cells. To u...

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Bibliographic Details
Main Authors: Caijuan Zhan, Gholamreza Bidkhori, Hubert Schwarz, Magdalena Malm, Aman Mebrahtu, Ray Field, Christopher Sellick, Diane Hatton, Paul Varley, Adil Mardinoglu, Johan Rockberg, Veronique Chotteau
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:iScience
Subjects:
Bioengineering
Biophysics
Cell Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220308452

Internet

http://www.sciencedirect.com/science/article/pii/S2589004220308452

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