Transmembrane Helices 7 and 8 Confer Aggregation Sensitivity to the Cystic Fibrosis Transmembrane Conductance Regulator

Transmembrane Helices 7 and 8 Confer Aggregation Sensitivity to the Cystic Fibrosis Transmembrane Conductance Regulator

The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a large multi-spanning membrane protein that is susceptible to misfolding and aggregation. We have identified here the region responsible for this instability. Temperature-induced aggregation of C-terminally truncated versions of CFTR...

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Bibliographic Details
Main Authors: Bertrand Kleizen, Eduardo de Mattos, Olga Papaioannou, Michele Monti, Gian Gaetano Tartaglia, Peter van der Sluijs, Ineke Braakman
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
CFTR
aggregation
TMD2
TM7
TM8
instability
Online Access:https://www.mdpi.com/1422-0067/24/21/15741

Internet

https://www.mdpi.com/1422-0067/24/21/15741

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